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It is currently admin-istered every 2 weeks with doses varying between 15 and 60 U/kg/infusion. Unfortunately, there is signi? cantinterobserver variability in the assessment of aleak at extubation: it is dependent upon headposition, sedation, and presence of secretions inthe airway.
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Any dose not administered at the recommended ageshould be administered at a subsequent visit, when indicated and feasible.